NADPH dehydrogenase

spinqualitylabelsall models Structure of yeast NADPH dehydrogenase complex with FMN, p-hydroxybenzaldehyde and Mg+2 ion (green) (PDB code 1k03). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function NADPH dehydrogenase or old yellow enzyme or NADH:flavin oxidoreductase/NADH oxidase or prostaglandin F2A synthase or chromate reductase (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor. See NAD(P)H. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. NADPH dehydrogenase quinone 1 (NQO1) reduces quinones to hydroquinones. NADPH dehydrogenase quinone 2 (NQO2) catayzes electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain. Structural highlights OYE cofactor FMN interacts with the ligand in active site. Water molecules are shown as red spheres.

3D Structures of NADPH dehydrogenase

Updated on 24-March-2026

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• NADPH dehydrogenase
  • NAD(P)H – OYE + FMN - fungus
    
  • 1oyc, 1oya – yOYE + FMN - yeast
    
  • 1oyb – yOYE + FMN + p-hydroxybenzaldehyde
    
  • 3tjl – SsOYE + FMN + malonate - Scheffersomyces stipitis
    
  • 6s32 – OYE + FMN + benzamidine – Chroococcidiopsis thermalis
    
  • 6s31 – GsOYE + FMN + benzaldehyde – Galdieria sulphuraria
    
  • 6s0g, 6s23 – GsOYE + FMN
    
  • 6agz – OYE + FMN - Pichia
    
  • 3kru, 3krz – OYE + FMN – Thermoanaerobacter pseudethanolicus
    
  • 3atz – TcOYE + FMN + benzaldehyde – Trypanosoma cruzi
    
  • 3aty – TcOYE + FMN
    
  • 2gou, 2gqa – SoOYE + FMN – Shewanella oneidensis
    
  • 2gq9 – SoOYE + FMN + benzaldehyde
    
  • 7o0t – OYE + FMN – Chloroflexus aggregans
    
  • 3hf3 – TsOYE + FMN – Thermus scotoductus
    
  • 3hgj – TsOYE + FMN + benzaldehyde
    
  • 8uat – TsOYE + FMN + pyridine derivative
    
  • 8uaj – TsOYE + FMN + succinate
    
  • 9iuv – OYE (mutant) + FMN – Parageobacillus thermantarcticus
    
  • 8pun – OYE + FMN – Ferrovum
    
• NADPH dehydrogenase 1
  • 4rnu, 4rnw, 4rnx – yOYE 1 + FMN
    
  • 1k02, 4h6k, 4k7y – yOYE 1 (mutant) + FMN
    
  • 1bwk, 1bwl – OYE 1 (mutant) + FMN - Candida albicans
    
  • 8x0j – GkOYE (mutant) – Geobacillus kaustophilus
    
  • 3gr7, 3gr8 – OYE + FMN – Geobacillus kaustophilus
    
  • 4rnv, 5v4p – yOYE 1 + FMN + p-hydroxybenzaldehyde
    
  • 1k03 – yOYE 1 (mutant) + FMN + p-hydroxybenzaldehyde
    
  • 3rnd – yOYE 1 mutant) + FMN + hydroxymethyl cyclopent-2-en-one
    
  • 4yil, 4ync – yOYE 1 (mutant) + FMN + acrylate derivative
    
  • 4gbu, 4gxm – yOYE 1 (mutant) + FMN + methyl propenyl phenol
    
  • 4ge8, 3txz, 4gwe, 4h4i, 4k7v, 4k8e, 4k8h – yOYE 1 (mutant) + FMN + carvone
    
  • 3tx9 – yOYE 1 + FMN + hydroxymethyl cyclopent-2-en-one
    
  • 8j59 – OYE 1 + FMN - Aspergillus flavus
    
• NADPH dehydrogenase 2
  • 7bn7, 9fh7 – yOYE 2 + FMN
    
  • 9kuh – yOYE + FMN + pyridine derivative
    
• NADPH dehydrogenase 2.6
  • 4qai – SsOYE 2.6 (mutant) + FMN
    
  • 4m5p – SsOYE 2.6 + FMN + malonate
    
  • 3upw – SsOYE 2.6 + FMN + malonate + nicotineamide
    
  • 4df2 – SsOYE 2.6 + FMN + malonate + chlorophenol
    
• NADPH dehydrogenase 3
  • 5v4p – yOYE 3 + FMN + p-hydroxybenzaldehyde
    
  • 5v4v – yOYE 3 + FMN + nicotinamide
    
• NADPH dehydrogenase 4
  • 4b5n – SoOYE 4 + FMN
    
• NADPH dehydrogenase quinone 1
  • 5a4k – hNQO1 (mutant) + FAD - human
    
  • 5fuq, 4cet – hNQO1 (mutant) + FAD + dicoumarol
    
  • 4cf6 – hNQO1 (mutant) + FAD + cibacron blue
    

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