NK cell receptor

spinqualitylabelsall models Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry 1kcg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Natural killer (NK) cell receptors are located on the innate immune system NK cells. The receptors are differentiated into those activating effector function and those inhibiting it. The receptors induce apoptosis upon binding ligands which indicate infection. NKG2D is expressed in NK cells, cytotoxic T cells and T cell subsets. NKP are CD122(+) NK cell precursors. 2B4 (CD244) are expressed on all NK cells, T cell subset, monocytes and basophils. Ly49 are lectin-type receptors expressed in NK cells and T cell subsets. KIR are immunoglobulin-type receptors. Relevance NKG2D is associated with response to cellular distress and infection.

3D structures of NK cell receptor

Updated on 23-March-2026

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• Activating NK cell receptors
• NKG2D extracellular domain 80-216
  • 1mpu – hNKG2D – human
    
  • 1hyr, 7fi5, 7fi6, 7fi7, 7fi8, 7fi9 – hNKG2D + class I MHC-like ligand MICA
    
  • 8tm0 – hNKG2D + class I MHC ligand
    
  • 1kcg – hNKG2D + class I MHC-like ligand ULBP3
    
  • 4s0u – hNKG2D + retinoic acid early transcript 1L protein
    
  • 4pp8 – mNKG2D + retinoic acid early-inducible protein 1β
    
  • 4pdc – hNKG2D + cowpox virus protein
    
  • 3bdw – hNKG2D + CD94
    
  • 3bdw, 3cii – hNKG2D + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen
    
  • 8ea5, 8ea6, 8ea7, 8ea8, 8ea9, 8eaa, 8eab, 8se5, 8se6 – hNKG2D + inhibitor
    
  • 9dh2 – hNKG2D + antibody
    
  • 1hq8 – mNKG2D – mouse
    
• NKp
  • 6yjp – hNKp30 IG domain 19-130 + hNKp30 ligand
    
  • 1hkf – hNKp44 IG domain
    
  • 1oll, 1p6f – hNKp46 extracellular domain 25-212
    
  • 8qmd – hNKp80 extracellular domain
    
• 2B4
  • 1z2k – h2B4 D1 domain - NMR
    
  • 2ptu – m2B4 D1 domain
    
  • 2ptt – h2B4 D1 domain + CD48 antigen
    
• Ly49
  • 3g8l, 3g8k – mLy49 C-type lectin-like domain
    
• CD94 See CD94
• Inhibitory NK cell receptors
• KIR or killer cell immunoglobulin-like receptor extracellular domain 22-225
  • 3wyr – hKIR2dl4
    
  • 3h8n – hKIR2ds4
    
  • 3vh8, 3wuw, 5b38, 5b39, 5t6z, 5t70, 6v3j, 7duu, 7k80, 9bl2, 9bl5, 9d96, 9d97 – hKIR3dl1 + MHC class I antigen B + β-2-microglobulin + peptide
    
  • 6pag – hKIR3dl3 + MHC class I antigen B + β-2-microglobulin + peptide
    
  • 6pa1 – hKIR2dl2 + MHC class I antigen B + β-2-microglobulin + peptide
    
  • 4n8v – hKIR2ds2 + MHC class I antigen B + β-2-microglobulin + peptide
    
• KLRG1
  • 3fft – hKLRG1 + cadherin
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky