Negative elongation factor

spinqualitylabelsall models Human NELF A (grey) complex with NELF C/D (green) and Cl- ion (green) (PDB code 5l3x) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Negative elongation factor (NELF) induces RNA polymerase II promoter proximal pausing and limits provirus expression in HIV-infected T cells. Disease NELF has been implicated in various diseases ranging from neurological disorders to cancer.

3D structures of negative elongation factor

Updated on 24-March-2026

5l3x - hNELF A + NELF C/D - human
2bz2, 1x5p, 2jx2 - hNELF E RNA recognition motif - NMR
8jj6 - hNELF B + NELF C/D
6gml, 8uha, 8uhd, 8uhg, 8ui0, 8uis, 8w8e - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - Cryo EM
7ycx - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + RPB12 + DNA + RNA - Cryo EM
9j0n, 9j0p, 9j0o - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + nucleosome + DNA + RNA - Cryo EM
9vd9 - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + DNA + RNA - Cryo EM
7pks - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + serine/threonine-protein phosphatase + DNA + RNA - Cryo EM
8rbx - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + nucleosome + serine/threonine-protein phosphatase + DNA + RNA - Cryo EM

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Michal Harel