Neurexin

spinqualitylabelsall models Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry 2xb6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See: Neurodevelopmental Disorders Neuroligin-Neurexin Interaction Relevance NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases. Structural highlights The surface interaction between NRXN and neuroligin is mediated by a Ca+2 ion. Water molecules are shown as red spheres.

3D Structures of Neurexin

24-March-2026

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• Neurexin
  • Neuroligin – hNRXN-1b + LRRTM2 – human
    
  • Neurodevelopmental Disorders – mNRXN-1α LNS domain+splice insert 4 – mouse
    
  • Neuroligin-Neurexin Interaction, 3bop - mβNRXN-1 residues 1132-1246 + mb-NRXN-2 residues 1277-1334
    
  • 3mw4 - mβNRXN-3 residues 854-1027
    
  • 6pnp, 6pnq - mNRXN-1 LNS2 domain + neurexophilin-1
    
  • 2r1b, 3mw3 - rNRXN-1α LNS domain+splice insert 4 – rat
    
  • 2r16 - rNRXN-1α LNS domain+Ca
    
  • 1c4r - rNRXN-1α LNS domain
    
  • 2r1d - rNRXN-1β LNS/LG domain
    
  • 2h0b - bNRXN-1α LNS2 domain – bovine
    
  • 6cw1 - bNRXN-1 LNS2-LNS3 domains
    
  • 3asi - bNRXN-1α LNS5-EGF3-LNS6 domains
    
  • 3poy - bNRXN-1α LNS2-LNS6 domains (mutant)
    
  • 3qcw, 3r05 - bNRXN-1α LNS1-LNS6 domains (mutant)
    
• NRXN+Neuroligin
  • 2wqz, 2xb6 – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
    
  • 3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
    
  • 3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain
    
  • 3vkf - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
  • 8g7y, 8g7z, 8g80, 8g81 - mNRXN-1β + mNLGN-2 – Cryo EM

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Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman