Nonstructural protein

spinqualitylabelsall models Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Nonstructural protein (NS) is a protein encoded by a virus which is not part of the viral particle. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NS User:Michael Strong/H1N1/NS1/MSA User:Michael Strong/H1N1/NS2/MSA Student Project 4 for UMass Chemistry 423 Spring 2015. For NS1 of SARS-CoV-2 see SARS-CoV-2 protein NSP1. For NS2 of SARS-CoV-2 see SARS-CoV-2 protein NSP2. For NS3 of SARS-CoV-2 see SARS-CoV-2 enzyme Papain-like. For NS4 of SARS-CoV-2 see SARS-CoV-2 protein NSP4. For NS6 of SARS-CoV-2 see SARS-CoV-2 protein NSP6. For NS7 or replicase polyprotein 1ab light chain of SARS-CoV-2 see SARS-CoV-2 protein NSP7. For NS8 or replicase polyprotein 1ab heavy chain of SARS-CoV-2 see SARS-CoV-2 protein NSP8. For NS9 of SARS-CoV-2 see SARS-CoV-2 protein NSP9. For NS10 or replicase polyprotein 1ab of SARS-CoV-2 see SARS-CoV-2 protein NSP10. For NS12 of SARS-CoV-2 see also Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi. For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see SARS-CoV-2 enzyme RdRp. SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called replication-transcription complex. For NS16+NS10 of SARS-CoV-2 see SARS-CoV-2 enzyme 2'-O-MT. For NS13 of SARS-CoV-2 see Unwinding the helicase NSP13. Relevance The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See Bailey Dove/Victrelis. Structural highlights Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions. 3D Structures of Nonstructural protein Nonstructural protein 3D structures

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Alexander Berchansky, Michal Harel