Nuclear receptor coactivator

spinqualitylabelsall models Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, 1oj5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors. NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response. NCOA2 is a DNA transcription coactivator with glucocorticoid receptor. NCOA3 shows histone acetyltransferase activity. NCOA5 is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor. NCOA7 may be a driver for beast cancer metastasis See also: Glucocorticoids and Steroid Hormones and their receptors. . Structural highlights NCOA/STAT6 transactivator domain LXXLL peptide interactions. 1st Iod coordination site. 2nd Iod coordination site. Water molecules are shown as red spheres. 3th and 4th Iod coordination sites. 5th Iod coordination site.

3D structures of nuclear receptor coactivator

Updated on 17-July-2024

Glucocorticoids – hNCOA1 residues 920-970 + CREB-binding protein – human
Steroid Hormones and their receptors, 6es7, 6sqc – hNCOA3 1040-1086 + CREB-binding protein – NMR
1v95 – hNCOA5 anticodon binding domain 197-313 – human – NMR
8arp – hNCOA7 781-942
1oj5 – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse
5y7w - mNCOA1A Pas-B domain + YL-2 peptide

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