Nuclear transcription factor Y

spinqualitylabelsall models Human nuclear transcription factor Y subunitα (cyan), subunit β (green) and subunit γ (pink) complex with HSP70 promoter DNA fragment (PDB code 4awl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nuclear transcription factor Y (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence. See details in NF-Y Transcription Factor. Relevance NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer. Structural highlights Human nuclear transcription factor Y subunit α, subunit β, subunit γ with HSP70 promoter fragment (PDB code 4awl). The interaction of NFY with the promoter CCAAT sequence, involves an insertion of an NFY helix into the minor groove of the DNA.

3D Structures of nuclear transcription factor Y

Updated on 26-March-2026

NF-Y Transcription Factor, 4awl, 7ah8 – hNFY beta+gamma subunits - human
4awl – hNFY alpha+ beta+gamma subunits + promoter DNA
6qmp, 6qmq, 6qms, 8qu2, 8qu3, 8qu4 – hNFY alpha peptide+beta+gamma subunits
5g49 – AtNFY beta6+gamma3 subunits – Arabidopsis thaliana
6r0m, 6r0n – AtNFY beta2+gamma3 subunits histone-fold domain
6r2v – AtNFY alpha6+ beta2+gamma3 subunits + DNA
7cvq – AtNFY beta2+gamma3 subunits + DNA
7cvo – AtNFY beta2+gamma3 + gamma4 subunits + DNA
7c9p – rNFY beta11+gamma2 subunits – rice
7c9o – rNFY beta11+gamma2 subunits + zinc finger protein HD1 + DNA
6r0l – rNFY gamma7 subunit + OsGhd8

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman