Nucleolin

spinqualitylabelsall models Hamster nucleolin RNA recognition motifs 1-2 (blue) complex with RNA (green) (PDB code 1rkj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nucleolin (NCL) is a multifunctional phosphoprotein found in the nucleolus, nucleus and cytoplasm. NCL contains intrinsic DNA and RNA helicase, nucleic-acid-dependent ATPase and self-cleaving activities. NCL binds RNA through its RNA recognition motifs (RBD). It regulates various aspects of DNA and RNA metabolism. Relevance NCL expression is enhanced on the surface of many different types of cancer cells and hence is the target of anti-cancer therapies. NCL is a specific marker of angiogenic endothelial cells in tumor vessels. Structural highlights The RNA loop is sandwiched between RBD 1 and 2 interacting with both NCL domains. RNA-protein interactions.

3D structures of nucleolin

Updated on 26-March-2026

9cb5 – hNCL + antibody + DNA – human
2krr – hNCL RBD1-2 - NMR
2fc8, 2fc9 – hNCL RRM_1 domain - NMR
1rkj, 1fje – haNCL RBD1-2 + RNA – hamster - NMR
1fj7 – haNCL RBD1 - NMR
1fjc – haNCL RBD2 - NMR

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