O-GlcNAcase

spinqualitylabelsall models Human OGA complex with transition state analog (PDB code 5m7s Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function O-GlcNAcase or hyaluronoglucosaminidase (OGA) is one of two enzymes which modulate the level of O-linked N-acetylglucosamine (O-GlcNAc) attachment to cytoplasmic, nuclear and mitochondrial proteins. The attachment of O-GlcNAc to proteins is a post-translational modification. Relevance Inhibition of OGA is a promising therapeutic approach to treat tau pathology in neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. The inhibition of OGA hinders formation of tau aggregates and decreases neuronal cell loss. Structural highlights The 3D structure of the complex between human OGA and a transition state analog Thiamet-G shows the active site pocket at the base of a V-shaped cleft between the 2 OGA monomers. There are numerous H-bonds formed between OGA and Thiamet-G as well as some hydrophobic interactions. Two Asp residues are defined as catalytic residues.

3D structures of O-GlcNAcase

Updated on 06-April-2026

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• O-GlcNAcase
  • 6hki, 5m7r - hOGA - human
    
  • 9ne4, 9ne5, 9qen - hOGA – Cryo EM
    
  • 5huk, 5uhp, 5vvo - hOGA TIM barrel 56-400 and stalk 544-705 domains
    
  • 6r45 - OGA HAT-like domain 513-723 - Trichoplax adhaerens
    
  • 2vur, 2v5c, 2v5d - CpOGA - Clostridium perfringens
    
  • 2jh2 - CpOGA cohesin domain 768-909
    
  • 2w1n - CpOGA cohesin+fibronectin domains 768-1001
    
  • 9lr5 - BtOGA residues 22-737 (mutant) - Bacterioides thetaiotaomicron
    
  • 2o4e - BtOGA residues 768-999 - NMR
    
  • 2xsa - OgOGA - Oceanicola granulosus
    
• O-GlcNAcase complex with small molecule
  • 5m7u, 9ba9 - hOGA + inhibitor
    
  • 6pm9, 5uhl - hOGA TIM barrel and stalk domains + inhibitor
    
  • 5m7s - hOGA + transition state analog
    
  • 5un9 - hOGA TIM barrel and stalk domains + transition state analog
    
  • 5m7t - hOGA + PUGNAc derivative
    
  • 5uho - hOGA TIM barrel and stalk domains + PUGNAc
    
  • 5mi6 - hOGA + transition state analog + inhibitor
    
  • 2j62 - CpOGA + GlcNAcstatin
    
  • 2wb5, 2x0y, 2xpk, 5oxd - CpOGA + inhibitor
    
  • 7khv - CpOGA (mutant) + pyrimidine derivative
    
  • 2vvs, 2wca - BtOGA + PUGNAc
    
  • 2j4g, 2w4x, 2vvn, 2w66, 2w67, 2xj7, 2xm1, 4aiu, 4ais, 2wzi, 2wzh, 4ur9, 5fky, 5fl0, 5fl1, 7ou6, 7ou8 - BtOGA + inhibitor
    
  • 5mi4 - BtOGA (mutant) + inhibitor
    
  • 2xm2 - BtOGA + LOGNAc
    
  • 5abf, 5abg, 5abh, 5abe - BtOGA + pyrrolidine derivative
    
  • 2jiw - BtOGA + epivalienamine derivative
    
  • 2j47 - BtOGA + PUGNAc derivative
    
  • 5mi5, 5mi7 - BtOGA + PUGNAc + inhibitor
    
  • 2x0h - BtOGA + michaelis complex
    
  • 2xsb - OgOGA + PUGNAc
    
  • 7khs - OgOGA catalytic domain 1-447 + pyrimidine derivative
    
  • 7k41 - EcOGA + inhibitor – Escherichia coli
    
• O-GlcNAcase complex with polypeptide
  • 5vvx, 5vvt, 5vvv, 5vvu, 5un8 - hOGA TIM barrel and stalk domains + peptide + NAG
    
  • 7yeh - hOGA 1-916 + O-GlcNac transferase + NAG + UDP
    
  • 8p0l - hOGA 1-916 + Ser + Cys- + NAG
    
  • 2yds, 2ydq, 4zxl, 6rhe, 2ydr - CpOGA (mutant) + peptide
    
  • 2ozn - CpOGA cohesin domain + hyaluronidase dockerin domain
    

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Michal Harel, Alexander Berchansky