Opioid receptor

spinqualitylabelsall models Structure ofκ-opioid receptor complex with opioid antagonist, citric acid, PEG and octadec-enoate derivative (PDB entry 4djh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Opioid receptor (OpR) is a G protein-coupled receptor with opioids as ligands. OpR types are classified according to the ligands which bind to them. The μ-opioid receptor binds morphine. For more details on μ-opioid receptor see Mu Opioid Receptor Bound to a Morphinan Antagonist Kratom μ Opioid Receptors Mu Opioid Receptor Antagonists 6dde μ-opioid receptor: G protein complex The κ-opioid receptor binds opium-type ligands. For details see Student Project 3 for UMass Chemistry 423 Spring 2015. The δ-opioid receptor binds enkephalins. For details see Delta opioid receptor. The Nociceptin/orphanin FQ opioid receptor binds the heptadecapeptide orphanin. See also Opioids Opioid receptors Treatments:Opioid drugs Tutorial: The opioid receptor, a molecular switch Transmembrane (cell surface) receptors Relevance Nociceptin/orphanin FQ opioid receptor plays a role in the regulation of reward and motivation of substance abuse and is a target of drug abuse medication. Its agonists are useful in treatment of pain, anxiety, edema and more and its antagonists are useful in pain management, depression, dementia and Parkinson disease. Structural highlights The κ-opioid receptor has a large binding pocket. Active site. Water molecules are shown as red spheres.

3D structures of opioid receptor

Updated on 12-April-2026

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• δ-opioid receptor
  • G protein-coupled receptor – hOpR + peptide antagonist - human
    
  • opioids – hOpR + antagonist
    
  • Mu Opioid Receptor Bound to a Morphinan Antagonist – hOpR + GI + deltorphin – Cryo EM
    
  • Kratom – hOpR + GI + modulator – Cryo EM
    
  • μ Opioid Receptors, Mu Opioid Receptor – hOpR + GI + modulator + agonist – Cryo EM
    
  • Antagonists, 6dde – hOpR + GI + drug – Cryo EM
    
  • Student Project 3 for UMass Chemistry 423 Spring 2015 – hOpR + GI + peptide – Cryo EM
    
  • Delta opioid receptor – hOpR + GI + nanobody + peptide agonist– Cryo EM
    
  • Opioids – hOpR + GI + nanobody + inhibitor – Cryo EM
    
  • Opioid receptors, Treatments:Opioid drugs – hOpR + GI + nanobody + agonist – Cryo EM
    
  • 9ppw – hOpR + GI + nanobody + antagonist – Cryo EM
    
  • Transmembrane (cell surface) receptors – mOpR + antagonist - mouse
    
• κ-opioid receptor
  • 4djh – hOpR + opioid antagonist
    
  • 6vi4 – hOpR (mutant) + nanobody
    
  • 7yit – hOpR (mutant) + nanobody + cytochrome b562
    
  • 9l60 – hOpR + GI + dynorphin peptide – Cryo EM
    
  • 7y1f – hOpR + GI + nanobody + dynorphin peptide – Cryo EM
    
  • 8dzr – hOpR (mutant) + GI + nanobody + gustucin peptide – Cryo EM
    
  • 8feg – hOpR + GI + peptide – Cryo EM
    
  • 8cgj, 8vvg, 9d61 – hOpR + GI + agonist – Cryo EM
    
  • 9w49 – hOpR + GI + ligand – Cryo EM
    
  • 9v6o – hOpR + GI + drug – Cryo EM
    
  • 9mql – hOpR + quinoline derivative – Cryo EM
    
  • 9mqk – hOpR + antibody + nanobody + quinoline derivative – Cryo EM
    
  • 8dzq, 8vve, 8vvf – hOpR + GI + nanobody + ligand – Cryo EM
    
  • 8dzp, 8dzs – hOpR (mutant) + GI + nanobody + ligand – Cryo EM
    
• Nociceptin/orphanin FQ opioid receptor
  • 4ea3 – hOpR + peptide mimetic
    
  • 8f7w, 8f7x – hOpR + GI + nanobody + nociceptin peptide – Cryo EM
    
• μ-opioid receptor
  • 9mqh – hOpR – Cryo EM
    
  • 9wsv – hOpR + arrestin + DAMGO peptide – Cryo EM
    
  • 9wsx – hOpR + arrestin + antibody + opioid peptide – Cryo EM
    
  • 8qot – hOpR + nanobody
    
  • 8f7q, 8f7r, 9wsw – hOpR + GI + nanobody + endomorphin peptide – Cryo EM
    
  • 8ef6 – hOpR + GI + nanobody + morphine – Cryo EM
    
  • 7t2h, 7u2k, 8ef5, 8efb, 8efl, 8efo – hOpR + GI + nanobody + drug – Cryo EM
    
  • 9py2, 9py3, 9py4 – hOpR + GI + Imodium – Cryo EM
    
  • 9odk, 9odl – hOpR + GI + ligand – Cryo EM
    
  • 8efq, 9odm, 9odn, 9wst – hOpR + GI + DAMGO – Cryo EM
    
  • 8k9l – hOpR + GI + nanobody + DAMGO – Cryo EM
    
  • 9odf – hOpR + GI + agonist – Cryo EM
    
  • 9ode, 9odg, 9odj, 9pxv, 9pxw, 9pxx, 9pxy – hOpR + GI + drug – Cryo EM
    
  • 8y73 – hOpR + nanobody + peptide – Cryo EM
    
  • 9bjk – hOpR + nanobody + drug – Cryo EM
    
  • 8k9k, 9bqj – hOpR + GI + nanobody + agonist – Cryo EM
    
  • 8y72 – hOpR + GI + nanobody + modulator – Cryo EM
    
  • 8efb, 8efl – hOpR + GI + nanobody + drug – Cryo EM
    
  • 9pxu – hOpR + antibody + nanobody + drug – Cryo EM
    
  • 9ppq – hOpR + inhibitor – Cryo EM
    
  • 8efo, 9o36 – hOpR + GI + nanobody + inhibitor – Cryo EM
    
  • 9mqi – hOpR + antibody + nanobody – Cryo EM
    
  • 9mqj – hOpR + quinoline derivative – Cryo EM
    
  • 4dkl, 5c1m – mOpR + opioid antagonist
    
  • 6ddf – mOpR + GI + DAMGO peptide – Cryo EM
    
  • 7u2l – mOpR + GI + nanobody – Cryo EM
    
  • 6dde – mOpR + GI + nanobody + DAMGO peptide – Cryo EM
    
  • 7t2g – mOpR + GI + antagonist – Cryo EM
    
  • 7scg – mOpR + GI + nanobody + antagonist – Cryo EM
    

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