Pantothenate kinase

spinqualitylabelsall models Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, 2f9w Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. Three types of PanK are known. PanK I found in bacteria PanK II found mostly in eukaryotes PanK III found in bacteria and known as CoaX. Disease Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration. Structural highlights Pantothenate binds in a buried pocket at the PanK dimer interface. Buried pocket at the PanK dimer interface. 3D structures of pantothenate kinase Pantothenate kinase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman