Period circadian protein

spinqualitylabelsall models Mouse PER2 homolog Cry domain (green) complex with cryptochrome-1 (deep sky blue), PEG400, Cl- (green) and Zn+2 (grey) ions (PDB code 4ct0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Period circadian protein (PER) is essential for the biological clock function. An increase in PER leads to shortening of the circadian rhythms and its decrease leads to lengthening of it. PER1 has a role in regulation of genes involved in renal sodium reabsorption and in blood pressure control. PER2 may affect neurobiological activities like sleeping, depression and addictionis the primary circadian pacemaker in the brain. PER3 is the primary circadian pacemaker in the brain Disease Disturbances in the expression of PER1, PER2 and PER3 is seen in most breast cancerous cells and is probably due to methylation of their promoter. Structural highlights There are numerous interactions between PER and cryptochrome. The strongest are those formed by the cryptochrome terminal helix and by the Zn+2 ion which forms tetrahedral interactions: 2 with PER and 2 with cryptochrome. Cl coordination site. Water molecules are shown as red spheres.

3D Structures of period circadian protein

Period circadian protein 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman