Phenylethanolamine N-methyltransferase

spinqualitylabelsall models Human phenylethanolamine N-methyltransferase with adenosyl homocysteine complex with substrate noradrenochrome (PDB entry 3hcb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. Relevance PNMT activity is decreased in Alzheimer disease patients. Structural highlights The active site of PNMT contains the substrate and AdoHcy. Water molecules are shown as red spheres. Whole binding site.

3D Structures of Phenylethanolamine N-methyltransferase

Phenylethanolamine N-methyltransferase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel