Phenylpyruvate decarboxylase

spinqualitylabelsall models Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion 2q5o Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phenylpyruvate decarboxylase (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme. Structural highlights PPDC active site contains the ThDP cofactor and the phenypyruvate substrate. ThDP cofactor/phenypyruvate substrate binding site. Water molecules are shown as red spheres. Mg coordination site.

3D Structures of phenylpyruvate decarboxylase

Updated on 29-April-2026

2q5j, 2q5l – AbPPDC + deaza-ThDP derivative – Azospirillum brasilense

2q5o - AbPPDC + deaza-ThDP + phenylpyruvate

2q5q - AbPPDC + deaza-ThDP + phenylvalerate

2nxw – AbPPDC + TPP

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