Phosphoinositide phosphatase

spinqualitylabelsall models Human 5PTase complex with phosphoinositol 4-phospate, glycerol, sulfate, Cl- (green) and Mg+2 (light green) ions (PDB code 3mtc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phosphoinositide phosphatase degrades phosphoinositide signals. PTEN is phosphatidylinositol 3,4,5-triphosphate 3-phosphatase and dual-specificity protein phosphatase. For details of PTEN phosphatase see PTEN PTEN function PTEN (Hebrew) Disease Mutations in the Sac phosphatase lead to degenerative neuropathy. Structural highlights The substrate binds to one terminus of the β sandwich. Alpha Helices,  Beta Strands ,  Loops , Turns. Substrate phosphoinositol 4-phospate binding site. Water molecules are shown as red spheres. Mg+2 coordination site. Cl- coordination site (PDB code 3mtc).

3D Structures of phosphoinositide phosphatase

Updated on 10-May-2026

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• Phosphoinositide phosphatase
  • PTEN – hPTEN (mutant) – human
    
  • PTEN function – mPTEN – mouse
    
  • PTEN (Hebrew) – mPTEN + PI(5)P
    
  • 3mtc – ySac1 – yeast
    
  • 4tu3 – ySac1 + Vps74
    
  • 4xuu – hSac2
    
  • 4fye, 4fyf, 4fyg – SidF – Legionella pneumophila
    
• Phosphoinositide 5-phosphatase
  • 3n9v – h5PTase
    
  • 3mtc – h5PTase + phosphatidylinositol 4-phosphate
    
  • 4cml – h5PTase + phosphatidylinositol 3,4-bisphosphate
    
  • 5a7i – h5PTase + biphenyl hexakisphosphate
    
  • 5a7j – h5PTase + benzyl tetrakisphosphate
    
  • 2kig – m5PTase
    

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