Phospholipase A1

spinqualitylabelsall models Phospholiase A1 complex with octylglucoside, glycerol and Ca+2 ion (green) (PDB code 5dqz) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phospholipase A1 (PLA1) hydrolyzes phospholipids to produce 2-acyl-lysophospholipids and fatty acids. PLA1 preferentially hydrolyzes phosphatidic acid and PLA1-phosphatidic acid regulates mitochondria dynamics. Relevance Phosphatidylserine-specific PLA1 expression in colorectal cancer is associated with tumor invasion and metastasis.

3D Structures of phospholipase A1

Updated on 27-August-2023

4qnn – PLA1 – hornet
2yij – PLA1 IIγ – Arabidopsis thaliana
7x0c, 7x0d – PLA1 – Capsicum annuum
4hyq – PLA1 – Streptomyces albidoflavus
7ezz – PLA1 – Salmonella typhi

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Michal Harel, Joel L. Sussman