Phospholipase C

spinqualitylabelsall models Structure of phosphatidylinositol-specific phospholipase C complex with myo-inositol (PDB code 1ptg). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phospholipase C (PLC) or 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma cleaves phospholipids before the phosphate group. PLCs catalyze the conversion of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate and diacylglycerol. Phospholipase C β is a key enzyme in mammalian taste signal transduction. For more details on phospholipase C β see PLC beta 3 Gq. Phospholipase C γ is a physiological guanine nucleotide exchange factor for the nuclear GTPase. Phospholipase C δ is critical for Ca+2 homeostasis. Phospholipase C ε is an effector for Ras. Phosphatidylinositol-specific phospholipase C (PIPLC) catalyzes the hydrolysis of phosphatidylinositol into inositol triphosphate and deacylglycerol. PIPLC functions at the plasma membrane. PIPLC can release phosphatidylinositol-linked proteins (i.e., acetylcholinesterase) from the membrane by enzymatically cleaving their GPI anchor. . See also IP3 is second messenger. Disease Phospholipase C γ gene blocking can stop breast cancer. Phospholipase C δ has important suppressive role in the development and progression of esophageal carcinoma. Mutations in phospholipase C δ1 cause hereditary leukonychia. Mutations in phospholipase C ε1 are associated with stomach cancer risk and nephrotic syndromes. Structural highlights The active site of PIPLC is located at a solvent-accessible cleft at the C-terminal. Solvent-accessible cleft.

3D structures of phospholipase C

PLC beta 3 Gq

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman