Phospholipase D

spinqualitylabelsall models Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code 1v0y) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phospholipase D (PLD) hydrolyzes phosphatidylcholine (PC) into phosphatidic acid and choline. PLD is found in organisms ranging from virus to mammals. Relevance Dysregulation of lipid pathways is involved in many neurodegenerative disorders like Alzheimer disease. Brains of Alzheimer disease patients show decreased levels of PC and increased activity of PLD. Structural highlights The active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine. Water molecule are shown as red sphere. 3D structures of phospholipase D Phospholipase D 3D structures

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