Phosphomannomutase

spinqualitylabelsall models Human phosphomannomutase 1 complex withα-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry 2fue) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phosphomannomutase (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism. Disease Mutations in PMM2 cause carbohydrate-deficient glycoprotein syndrome type 1 (Jaeken syndrome). Structural highlights The PMM structure contains a core domain and a cap domain. It is known that in order for the substrate to bind, the cap must dissociate from the core domain and then re-associate to seal the active site from solvent molecules. The active site of PMM is located at the interface of the core and cap domains of the molecule. Water molecules are shown as red spheres.

3D Structures of phosphomannomutase

Phosphomannomutase 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman