Poly (ADP-ribose) polymerase

spinqualitylabelsall models Human glycosylated plasminogen complex with acetate, bicarbonate, K+ (purple) and Cl- (green) ions (PDB entry 4hhy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Poly (ADP-ribose) polymerase (PARP) or ADP-ribosyltransferase diphtheria toxin-like or ARTD is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP-1 and PARP-2 recognize and is activated by DNA breaks, . PARP-3 prevents from extensive end resection to promote double-strand DNA repair . PARP-4 deficiency causes splicing dysregulation . PARP-10 inhibits Myc transformation. It contains a RNA recognition motif (RRM). PARP-12 has roles in viral immunity and microRNA-mediated stress responses . PARP-14 promotes the survival of myeloma cells by binding and inhibiting JNK1 . Tankyrase (Tank1 and Tank2) are PARPs which regulate telomere length. Tank contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops). Relevance PARP inhibitors are investigated as mono therapy against breast cancer. Olaparib is a PARP inhibitor used as medication against ovarian cancer. Over-expression of PARP-14 rescues myeloma cells from apoptosis. Structural highlights PARP1 is composed of 3 domains. Among them are the N terminal DNA-binding domain which contains 5 zinc fingers (residues 1-97, 105-206, 207-366). The auto modification (AD) domain which contains a breast cancer 1 protein (BRCT) C-terminus domain (residues 386-485) and a WGR domain (rich in Trp, Gly and Arg) (residues 517-642). The C terminal domain which includes the catalytic domain (or PARP domain) (residues 662-1011). A potential drug binds at the active site pocket. 3D Structures of Poly (ADP-ribose) polymerase Poly(ADP-ribose) polymerase 3D structures

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