Function
Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor[1]. The translocase pathway contains:
- SecB - a chaperone protein[2]
- SecY, SecE, SecG or Sec61 an integral membrane complex
- SecD, SecF - proteins promoting the release of the mature peptide into the periplasm
- SecA - an ATPase unit[3].
For more details see SecA PBD motions.
3D structures of preprotein translocase
Preprotein translocase 3D structures
References
- ↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
- ↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
- ↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931
