Progestogens

spinqualitylabelsall models Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry 2w8y) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Progesterone Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone receptor. Human progesterone receptor ligand-binding domain bound with progesterone (1a28). Water molecules are shown as red spheres. Progesterone is a negative allosteric modulator of nicotinic acetylcholine receptors, and a potent antagonist of the mineralocorticoid receptor. Hydroxysteroid dehydrogenase, 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone.

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