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Function
Prolactin (PRL) is a hormone which has numerous effects. It enables females to produce milk. PRL provides the body with sexual gratification. PRL promotes neurogenesis in maternal and fetal brains. PRL stimulates cells which are responsible for the formation of myelin coating on axons[1].
See also Prolactin (Hebrew).
Disease
PRL has immunomodulatory effect and plays a role in lupus and rheumatoid arthritis[2]
- ↑ Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev. 2000 Oct;80(4):1523-631. PMID:11015620
- ↑ Chuang E, Molitch ME. Prolactin and autoimmune diseases in humans. Acta Biomed. 2007;78 Suppl 1:255-61. PMID:17465339
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3D Structures of prolactin
Updated on 07-October-2020
Prolactin (Hebrew) – hPRL – human - NMR
2q98 – hPRL (mutant)
3mzg, 3npz – hPRL + hPRL receptor extracellular domain
3d48, 3n06, 3n0p, 3ncb – hPRL (mutant) + hPRL receptor extracellular domain
3ncc, 3nce, 3ncf – hPRL (mutant) + hPRL receptor extracellular domain (mutant)
3ew3 – hPRL + rPRL receptor extracellular domain - rat
References
proteopedia link