Prolactin receptor

spinqualitylabelsall models Human prolactin receptor (deepskyblue) complex with prolactin (magenta), Na+ (purple) and Cl- (green) ions (PDB code 3mzg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Prolactin receptor (PRLR) mediates the prolactin hormone signal transduction cascade. Prolactin-dependent signaling occurs as a result of a ligand-induced dimerization of the PRLR. The PRLR can also bind to and be activated by growth hormone. See also: Cytokine receptors and Immune receptors Relevance The signaling action of PRLR/prolactin complex serve to control the pattern of gene expression that contributes to breast development and the pathobiology of breast cancer. Structural highlights Human prolactin receptor complex with prolactin, Na+ and Cl- (PDB code 3mzg). The interaction between PRLR and prolactin is strongly pH-dependent and is critically dependent on two histidine residues located at PRLP and on prolactin. Water molecules are shown as red spheres. Na coordination site is situated between PRLR and prolactin.

3D structures of prolactin receptor

Updated on 16-July-2026

growth hormone – hPRLR extracellular domain + hPRL - human
Cytokine receptors, Immune receptors, 3mzg, 3ncb – hPRLR extracellular domain + hPRL (mutant)
3ncc, 3nce, 3ncf – hPRLR extracellular domain (mutant) + hPRL (mutant)
3ew3, 3npz – rPRLR extracellular domain + hPRL - rat
4i18 - hPRLR extracellular domain + antibody
2lfg - hPRLR extracellular domain d2 - NMR
1f6f – rPRLR extracellular domain + placental lactogen
1bp3 – hPRLR extracellular domain + growth hormone
2n7i – hPRL receptor transmembrane domain 230-264 - NMR

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