Prostaglandin D synthase

spinqualitylabelsall models Human lipocalin prostaglandin D synthase complex with thiocyanate and Cl- ion (green) (PDB entry 2wwp) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Prostaglandin D synthase (PGDS) catalyzes the reversible conversion of 9α-11α-epidoxy-15-hydroxyprosta-5,13-dienoate to 9α-15-dihydroxy-11-oxoprosta-5,13-dienoate. Prostaglandin D2 synthase (PGD2S) catalyzes the conversion of prostaglandin H2 to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator in smooth muscle contraction. Human PGD2S has two isozymes: hematopoietic PGD2S found in mast cells see Glutathione S-transferase σ which is glutathione-dependent and lipocalin PGD2S found in the central nervous system, genital organs and heart. This enzyme is glutathione-independent and transports small hydrophobic molecules such as steroids. PGDS is a major constituent of cerebrospinal fluid. PGDS binds small lipophilic molecules like retinal and thyroid hormone. Relevance PGDS is believed to be a cause of baldness. PGD2S inhibitors are tested as potential anti-inflammation and anti-allergic drugs. Structural highlights Thiocyanate binding site. 1st Cl coordination site. Water molecule is shown as red sphere. 2nd Cl coordination site.

3D structures of prostaglandin D synthase

Updated on 20-July-2026

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• Prostaglandin D synthase glutathione-dependent
  • Glutathione S-transferase, 3kxo – hPGDS + glutathione + inhibitor – human
    
  • 5h5l – PGDS – Nilaparvata lugens
    
• Lipocalin PGD2S (Glutathione-independent)
  • 2wwp, 4imn, 5wy9 – hPGD2S
    
  • 4orr, 4ors, 4oru, 4orw, 4orx, 4ory, 4os0, 4os3, 4os8 - hPGD2S (mutant)
    
  • 8hta - hPGD2S (mutant) - NMR
    
  • 4imo - hPGD2S + substrate analog
    
  • 3o19, 3o22, 3o2y - hPGD2S (mutant) + oleate + palmitate
    
  • 2vcq, 2vcw, 2vcx, 2vcz, 2vd0, 2vd1 – hPGD2S + glutathione + inhibitor
  • 2e4j, 2rq0 - mPGD2S (mutant) – mouse – NMR
    
  • 2ktd - mPGD2S (mutant) + substrate analog – NMR
    
  • 2czt, 2czu – mPGD2S (mutant)
    

Hematopoietic PGD2S (Glutathione-dependent) or HGTS1 see Glutathione S-transferase σ

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