Prostaglandin E synthase

spinqualitylabelsall models Human PGES complex with inhibitor and glutathione (PDB code 4yl0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Microsomal Prostaglandin E synthase (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2 . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory glucocorticoids. Prostaglandin E synthase 1, Prostaglandin E synthase 2 and Prostaglandin E synthase 3 are involved in the biosynthsis of prostaglandin E1, E2 and E3 correspondingly. See also: Glucocorticoids; Steroid Hormones and their receptors.. Relevance PGES participates in several pathophysiological states in which COX-2 is involved and hence represents a potential target for anti-inflammatory and anti-cancer drug development . Structural highlights Microsomal Prostaglandin E synthase is membrane-associated (coordinates are from OPM database. The anti-inflammatory inhibitor binds to PGES in a pocket above the glutathione and interacts with various side-chains of a helix. Water molecules are shown as red spheres. 3D Structures of prostaglandin E synthase Prostaglandin E synthase 3D structures

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