Protein DJ-1

spinqualitylabelsall models Human DJ-1 complex with inhibitor isatin and Cl-1 (green) (PDB code 6afa). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Protein DJ-1 or DJ-1 or PARK7 or protein/nucleic acid deglycase DJ-1 or protein deglycase DJ-1 or RNA-binding protein regulatory subunit is a cancer- and Parkinson Disease-associated protein which protects cells from toxic stresses. Dj-1 is an antioxidant and functions in transcription modulatory activity. Disease The loss of DJ-1 leads to deficits in the detoxification enzyme NADP-quinone oxidoreductase. Mutations in DJ-1 caused early onset of Parkinson disease. Structural highlights The 3D structure of DJ-1 complex with the inhibitor isatin shows the covalent bond formed between isatin and DJ-1 conserved residue C106 as well as the numerous H-bonding interactions between the inhibitor and the protein. Whole binding site. Water molecules are shown as red spheres. 3D structures of protein DJ-1 Protein DJ-1 3D structures

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Michal Harel, Alexander Berchansky