Pseudouridine synthase

spinqualitylabelsall models tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate 1ze2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pseudouridine is an abundant modified nucleoside found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the bond between base and ribose in uridine. There are two major types of enzymes that catalyze this reaction: RNA-guided pseudouridine synthase -- Some ribonucleoproteins (complexes of proteins and small RNAs) have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to select the site of modification through base-pairing with the target RNA molecule. Guide-independent pseudouridine synthase -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a guide-independent mechanism acting through protein-only enzymes to catalyze the isomerization. Structural highlights The conversion of uridine to pseudouridine is accompanied by a conformational change of pseudouridine synthase. tRNA pseudouridine synthase binding with pseudouridine monophosphate (1ze2). 3D Structures of pseudouridine synthase Pseudouridine synthase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Angel Herraez, Jaime Prilusky, Wayne Decatur