Purine nucleoside phosphorylase

spinqualitylabelsall models Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Purine nucleoside phosphorylase (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. Disease PNP deficiency results in severe combined immunodeficiency. Structural highlights Residues 241-265 of PNP act as a gate that opens upon substrate binding. The ribose binding site is composed of mostly hydrophobic side chains. Active site. 3D structures of purine nucleoside phosphorylase Purine nucleoside phosphorylase 3D structures

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