| Function
Pyridoxal kinase (PDX) catalyzes the transfer of phosphate (Pi) from ATP to 5’ alcohol of pyridoxine, pyridoxamine and pyridoxal[1].
Structural highlights
PDX1 active site[2].
- ↑ di Salvo ML, Nogues I, Parroni A, Tramonti A, Milano T, Pascarella S, Contestabile R. On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5'-phosphate. Biochim Biophys Acta. 2015 Sep;1854(9):1160-6. doi: 10.1016/j.bbapap.2015.01.013., Epub 2015 Feb 3. PMID:25655354 doi:https://dx.doi.org/10.1016/j.bbapap.2015.01.013
- ↑ Safo MK, Musayev FN, di Salvo ML, Hunt S, Claude JB, Schirch V. Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases. J Bacteriol. 2006 Jun;188(12):4542-52. PMID:16740960 doi:188/12/4542
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3D Structures of pyridoxal kinase
Updated on 20-August-2026
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- Pyridoxal kinase
- 2f7k – hPDX - human
- 1lhp – sPDX – sheep
- 6yjz – mPDX - mouse
- 2ddm – EcPDX1 – Escherichia coli
- 3h74 – LpPDX – Lactobacillus planarum
- 3zs7 – PDX – Trypanosoma brucei
- 4c5j – SaPDX – Staphylococcus aureus
- 5tqi - PDX - Burkholderia multivorans
- 5trw - PDX - Burkholderia xenovorans
- 5b6a - PDX - Pseudomonas aeruginosa
- 5zw9 – ScPDX – Salmonella choleraesuis
- Pyridoxal kinase complex with pyridoxal compounds
- 3fhx – hPDX (mutant) + Mg + Na + ATP + pyridoxal + PLP
- 3keu – hPDX + Mg + ATP + PLP
- 1rft – sPDX + Zn + K + AMPPCP + pyridoxamine
- 1rfu – sPDX + Zn + ADP + PLP
- 2ddw – EcPDX1 + pyridoxal
- 4c5l – SaPDX + pyridoxal
- 4c5n – SaPDX + pyridoxal + AMPPCP
- 4s1i – EhPDX + Mg + PLP - Entamoeba histolytica
- 6su9 – PDX + pyridoxal + AMPPNP – Plasmodium falciparum
- 6k91, 6k92 – LdPDX + ADP + pyridoxine derivative – Leishmania donovani
- 6k90 – LdPDX + ADP + pyridoxamine
- 5zwa, 5zwb – ScPDX + ADP + PLP
- Other pyridoxal kinase complexes
- 2ajp – hPDX + Mg + ANP
- 2yxt – hPDX + Na + Pi
- 2yxu – hPDX + Mg + Na + ATP + Pi
- 3fhy – hPDX (mutant) + Mg + Na + ATP
- 4en4 – hPDX + Mg + ATP + ginkotoxin
- 4eoh – hPDX + Na + theophylline
- 8wr2 – hPDX + Na + luteoline
- 1lhr – sPDX + Zn + K + ATP
- 1rfv – sPDX + Zn + ADP
- 1ygj, 1ygk, 1yhj – sPDX + roscovitine
- 6yk0 – mPDX + ATPgS
- 6yk1 – mPDX + ATPgS + artesunate
- 2ddo – EcPDX1 + Mg + ATP + Pi
- 2i5b – PDX + ADP – Bacillus subtilis
- 6k8z – LdPDX + ADP
- 3hyo – LpPDX + Mg + ADP
- 3ibq – LpPDX + Mg + ATP
- 4c5k – SaPDX + ADP
- 4c5m – SaPDX + AMPPCP
- 4s1m – EhPDX + Mg
- 4s1h – EhPDX + Mg + ADP
References
