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Function
Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal[1].
Disease
Mutations in the protein are the cause of Familial Mediterranean fever[2].
- ↑ Fairbrother WJ, Gordon NC, Humke EW, O'Rourke KM, Starovasnik MA, Yin JP, Dixit VM. The PYRIN domain: a member of the death domain-fold superfamily. Protein Sci. 2001 Sep;10(9):1911-8. PMID:11514682 doi:https://dx.doi.org/10.1110/ps.13801
- ↑ Papin S, Cuenin S, Agostini L, Martinon F, Werner S, Beer HD, Grutter C, Grutter M, Tschopp J. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 2007 Aug;14(8):1457-66. Epub 2007 Apr 13. PMID:17431422 doi:https://dx.doi.org/10.1038/sj.cdd.4402142
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3D Structures of Pyrin domain
Pyrin domain 3D structures
References
