RNA uridylyltransferase

spinqualitylabelsall models RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry 2q0f) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function RNA uridylyltransferase or terminal uridylyltransferase or TUTase (TUT) catalyzes the addition of uridine to RNA. TUT acts as a suppressor of microRNA synthesis by mediating its terminal uridylation. For additional details on TUT-4 see Terminal Uridylyl Transferase. Drosophila melanogaster TUTase is called TUTase Tailor. It is forming the uridylation-mediated processing complex which degrades a variety ofncRNAs in the cytoplasm ,. Structural highlights TUT-4 active site contains UTP, UMP and Mg+2 ions. Water molecules are shown as red spheres. Mg coordination site.

3D Structures of RNA uridylyltransferase

Updated on 11-August-2024

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• RNA uridylyltransferase-1
  • Terminal Uridylyl Transferase – hTUT-1 RNA recognition motif – human – NMR
    
  • 3pq1 – hTUT-1 (mutant)
    
  • 6l3f – AtTUT-1 (mutant) – Arabidopsis thaliana
    
  • 6l8k – AtTUT-1 + UTP
    
  • 2b51, 5hcd – TbTUT-1 – Trypanosoma brucei
    
  • 5ido – TbTUT-1 + UTP
    
  • 5i49 – TbTUT-1 + UMPNPP
    
• RNA uridylyltransferase-4
  • 6iw6 – hTUT-4 253-723
    
  • 2q0c, 2q0d, 2q0e, 2q0f, 2q0g, 2ikf, 2nom, 5kal – TbTUT-4 + nucleotide
    
• RNA uridylyltransferase-7
  • 5w0b – hTUT-7 catalytic module
    
  • 5w0m – hTUT-7 + U5 ssRNA
    
  • 5w0o – hTUT-7 + dsRNA + UTPbr />
  • 5w0n – hTUT-7 + U2 ssRNA + UMPNPP
    
• TUTase Tailor
  • 5z4c – DmTUTT – Drosophila melanogaster
    
  • 5z4a, 5z4d, 5z4j, 6i0t, 6i0u, 6i0v – DmTUTT + RNA
    
  • 5z4m – DmTUTT (mutant) + UTP
    

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