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Function
Retinoblastoma-binding protein (RBBP) or histone-binding protein are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein[1].
- RBBP1 regulates transcriptional activity[2].
- RBBP2 demethylates histone H3 at lysine 4.
- RBBP2 homolog see KDM5B in Lysine-specific histone demethylase.
- RBBP5 is involved in methylation and dimethylation of histone H3[3].
- RBBP6 promotes p53 degradation[4].
- RBBP7 is a WD-repeat protein that interacts with histone deacetylases[5].
- RBBP9 blocks the binding of retinoblastoma protein to one of its signaling partners[6].
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Structural highlights
RBBP7 interacts with histone H4 in a pocket between its N-terminal α helix and its negatively charged PP loop which contains 2 consecutive Pro residues[7].
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3D structures of retinoblastoma-binding protein
Retinoblastoma-binding protein 3D structures
- ↑ Woitach JT, Zhang M, Niu CH, Thorgeirsson SS. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 Aug;19(4):371-4. PMID:9697699 doi:https://dx.doi.org/10.1038/1258
- ↑ Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al.. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov;8(11):3149-56. PMID:8414517
- ↑ Han J, Li T, Li Y, Li M, Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y. The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res. 2019 Sep 23. pii: 5572575. doi: 10.1093/nar/gkz819. PMID:31544921 doi:https://dx.doi.org/10.1093/nar/gkz819
- ↑ Motadi LR, Bhoola KD, Dlamini Z. Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology. 2011 Oct;216(10):1065-73. doi: 10.1016/j.imbio.2011.05.004. Epub, 2011 May 17. PMID:21676486 doi:https://dx.doi.org/10.1016/j.imbio.2011.05.004
- ↑ Yang J, Kiefer S, Rauchman M. Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes. Genomics. 2002 Oct;80(4):407-15. PMID:12376095
- ↑ Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein Pept Lett. 2012 Feb;19(2):194-7. PMID:21933118
- ↑ Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue ED. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008 Jul;16(7):1077-85. Epub 2008 Jun 19. PMID:18571423 doi:https://dx.doi.org/10.1016/j.str.2008.05.006
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