Retinoid X receptor

spinqualitylabelsall models Structure of human retinoid X receptorα ligand-binding domain complex with 9-cis retinoic acid (PDB entry 1fby) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Retinoid X receptor (RXR) is a nuclear receptor activated by 9-cis retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RXR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD). For additional details on RXR-α see RA Mediated T-reg Differentiation. See also Intracellular receptors There are 3 classes of RXR: α, β and γ. RXRα plays a pivotal role in liver metabolism. RXRγ mediates the anti proliferative effects of retinoid acid. Relevance RXRγ is involved in working memory and despair behavior. RXR pathway is a positive regulator of myelin debris clearance and has a role in age-related decline in remyelination. Structural highlights 9-cis retinoid acid binds to RXRα LBD in a hydrophobic pocket. Hydrophobic, Polar. Water molecules are shown as red spheres. 9-cis retinoid acid is in a hydrophobic pocket. The ligand-binding residues are conserved in the 3 classes of RXR . 3D structures of retinoid X receptor Retinoid X receptor 3D structures

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