Rho GTPase activating protein

spinqualitylabelsall models Human RhoGAP 1 (magenta) complex with RhoA (blue), GDP, MgF3 and Mg+2 ions (PDB code 1ow3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Rho GTPase activating protein (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions,. RhoGAPs contain a RhoGAP domain. RhoGAP7 activates the small GTPases RHOA, RHOB, RHOC and CDC42. RhoGAP9 regulates adhesion of hematopoietic cells to the extracellular matrix. RhoGAP11 causes cell-cycle arrest and apoptosis in response to DNA damage. RhoGAP12 may be involved in suppressing tumor formation. RhoGAP21 involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion. RhoGAP21 involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion. RhoGAP35 involved in cell adhesion, migration and invasion. Relevance RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy,. RhoGAP10 variants may be associated with schizophrenia. Structural highlights The active site of RhoGAP contains a catalytic arginine and GDP. Water molecules are shown as red spheres. Mg/MgF3 coordination site. 3D structures of Rho GTPase activating protein Rho GTPase activating protein 3D structures

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