Rho guanine nucleotide exchange factor

spinqualitylabelsall models Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code 3kz1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Rho guanine nucleotide exchange factor (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. Rho guanine nucleotide exchange factor 1 binds to G proteins and stimulate Rho-dependent signals. Rho guanine nucleotide exchange factor 3 acts on RHOA and RHOB involved in bone biology. Rho guanine nucleotide exchange factor 6 and Rho guanine nucleotide exchange factor 7 act on Rac1. Rho guanine nucleotide exchange factor 9 mutations involved in developmental and epileptic encephalopathy. Rho guanine nucleotide exchange factor 11 mediates Rho-myosin light chain signaling pathways at cell-cell junctions. Rho guanine nucleotide exchange factor 18 regulates tissue architecture and function via RhoA activation. Rho guanine nucleotide exchange factor 25 involved in contraction of vascular smooth muscle. Disease Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases . 3D Structures of Rho guanine nucleotide exchange factor Rho guanine nucleotide exchange factor 3D structures

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