Rhodocetin

spinqualitylabelsall models Rhodocetin heterotetramer subunitα (grey), β (green), γ (pink), δ (yellow) (PDB code 3gpr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Rhodocetin (Rtn) is a platelet aggregation inhibitor produced by the Malayan pit viper. Relevance Rhodocetin subunits αβ which selectively attacks tumor blood vessels and spares normal tissue vessels is studied as an anti-tumor. Structural highlights Rhodocetin 3D structure shows a tetramer of distinct homologous subunits α,β,γ and δ. The quaternary structure is distinct from that of snake venom CLPs. The γ,δ subunits are responsible for tn binding to integrin α-2 domain.

3D structures of rhodocetin

Updated on 07-May-2020

1sb2 - MpvRtn subunits αβ - Malayan pit viper
3gpr - MpvRtn subunits αβγδ
6nde, 6ndd, 6ndf, 6ndh, 6nda, 6ndc, 6ndb, 6nd8, 6ndg, 6nd9, 5thp - MpvRtn subunits γδ + integrin α-2 + ion

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