S-adenosylhomocysteine hydrolase

spinqualitylabelsall models Structure of rat S-adenosylhomocysteine hydrolase tetramer complex with NAD and adenine (PDB entry 1xwf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function S-adenosylhomocysteine hydrolase (AHCH) converts S-adenosylhomocysteine (AdoHcy) to L-homocysteine and adenosine. AHCH uses NAD+ as cofactor. AHCH is an essential enzyme in processes like transmethylation, trans-sulfuration and purine metabolism. Disease AHCH deficiency causes a genetic disorder of methionine metabolism. Structural highlights The biological assembly of rat S-adenosylhomocysteine hydrolase is homotetramer. AHCH structure contains 3 domains: catalytic, NAD-binding and C-terminal domain. The active site is located in a cleft between the catalytic domain and the NAD-binding domain and it contains the cofactor NAD and the product adenine.

3D structures of S-adenosylhomocysteine hydrolase

Updated on 14-November-2023

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• S-adenosylhomocysteine hydrolase
  • 1ky4 – rAHCH + NAD - rat
    
  • 1ky5 – rAHCH (mutant) + NAD
    
  • 1b3r – rAHCH catalytic domain + NAD
    
  • 1a7a – hAHCH + NAD – human
    
  • 3gvp – hAHCH SAHH-like domain + NAD
    
  • 3d64 – BpAHCH + NAD – Burkholderia pseudmallei
    
  • 3x2f – AHCH + NADH – Thermotoga maritima
    
• S-adenosylhomocysteine hydrolase complex with adenosine derivatives
  • 1d4f, 1xwf – rAHCH (mutant) + NAD + adenosine
    
  • 1k0u, 2h5l – rAHCH + NAD + adenosine analog
    
  • 1li4, 3nj4 – hAHCH + NAD + adenosine derivative
    
  • 1v8b – AHCH + NAD + adenosine – Plasmodium falciparum
    
  • 3dhy, 2ziz, 2zj0, 2zj1 – MtAHCH + NAD + adenosine derivative – Mycobacterium tuberculosis
    
  • 3ce6 – MtAHCH + NAD + adenosine
    
  • 3glq – BpAHCH + NAD + adenosine derivative
    
  • 3n58 – AHCH + NAD + adenosine – Brucella melitensis
    
  • 3ond – lAHCH + NAD + adenosine – lupin
    
  • 3one – lAHCH + NAD + adenine
    
  • 3onf – lAHCH + NAD + adenosine derivative
    
  • 5m66 – BeAHCH + NAD + adenosine – Bradyrhizobium elkanii
    
  • 5m5k – BeAHCH + NAD + adenosine + cordycepin
    
  • 5m67 – BeAHCH + NAD + adenosine + deoxyadenine
    
  • 3g1u – AHCH + NAD + adenosine – Leishmania major
    
• S-adenosylhomocysteine hydrolase other complexes
  • 5w49, 5w4b – hAHCH + NAD + inhibitor
    

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