SAICAR synthetase

spinqualitylabelsall models SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code 4fe2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function SAICAR synthetase (SAI) or phosphoribosylaminoimidazole-succinocarboxamide synthetase is part of the purine biosynthesis. SAI catalyzes ATP-dependent ligation of carboxyaminoimidazole ribotide (AICAR) with aspartate. Structural highlights SAI structure shows two domains. The active site is located in a hydrophilic tunnel between the 2 domains and contains ADP, aspartic acid and aminoimidazole-ribonucleotide (AIR). Residues are colored according to Hydrophobic, Polar. Water molecules are shown as red spheres. Surface representation of hydrophilic tunnel. Mg coordination site. Whole active site.

3D structures of SAICAR synthetase

Updated on 09-March-2022

{"openlevels":0}

• SAICAR synthetase
  • 1a48 – ySAI - yeast
    
  • 3r9r, 6yvq – MaSAI – Mycobacterium abscessus
    
  • 3kre – SAI – Ehrlichia chaffeensis
    
  • 1kut – SAI – Thermotoga maritima
    
• SAICAR synthetase complex
  • 2yzl – MjSAI + ADP – Methanocalcococcus jannaschii
    
  • 2z02 – MjSAI + ATP
    
  • 4fe2, 4nye – SpSAI + ADP + aspartate + AICAR – Streptococcus pneumoniae
    
  • 4fgr – SpSAI + ADP
    
  • 3nua – SAI + ADP + AMP – Clostridium perfringens
    
  • 2ywv – SAI + ADP – Geobsacillus kaustophilus
    
  • 2cnq – ySAI + ADP + AMP + succinate + AICAR
    
  • 2cnv – ySAI + aspartate + AICAR derivative
    
  • 2cnu – ySAI + aspartate
    
  • 1obd – ySAI + ATP + AMP
    
  • 1obg – ySAI + AMP
    
  • 2gqr – EcSAI + ADP – Escherichia coli
    
  • 2gqs – EcSAI + ADP + AICAR
    
  • 6yy6, 6yy7, 6yy8, 6yy9, 6yya, 6yyb, 6yyc, 6yyd, 6z0q, 6z0r – MaSAI + inhibitor
    
  • 6yx3 – MaSAI + ATP
    
• SAICAR synthetase type-1
  • 3u54 – PhSAI – Pyrococcus horikoshii
    
  • 4o81, 4o82, 4o83 – PhSAI + ADP + AMP
    
  • 4o84 – PhSAI + GMP
    
• SAICAR synthetase type-2
  • 3u55 – PhSAI
    
  • 4o7l, 4o7n – PhSAI + ADP
    
  • 4o7r – PhSAI + UMP + UDP
    
  • 4o7s – PhSAI + TMP + TDP
    
  • 4o7t – PhSAI + TMP + ADP + aspartate
    
  • 4o7v – PhSAI + UMP + UDP + ADP
    
  • 4o7w – PhSAI + ATP + TDP
    
  • 4o7y – PhSAI + CMP
    
  • 4o7z – PhSAI + GMP
    
  • 4o86 – PhSAI + ADP + CDP
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman