Function
Sequestosome (SQS) or p62, is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination[1].
Structural highlights
SQS is a multi-domain protein. SQS domain structure includes:
- PB1 domain which contains Phox and Berm1
- ZZ-type zinc finger
- SMIR – SOD interaction domain
- TB – TRAF6 binding motif
- LC3 – microtubule-associated protein 1 light chain 3B
- LIR – interaction region
- UBA – ubiquitin association domain.
Relevance
SQS is associated with fibrillary tangles in Alzheimer disease[2].
3D structures of sequestosome
Updated on 15-November-2023
Domains: PB1 1-102; ZZ 120-180; UBA 387-436
1q02, 2jy7, 2jy8, 2k0b, 2knv – hSQS UBA domain – human - NMR
6jm4 – hSQS-1 PB1 domain (mutant)
4uf8, 4uf9, 6tgy, 6th3 – hSQS-1 PB1 domain – Cryo EM
5yp7, 5yp8, 5ypa, 5ypb, 5ypc, 5ype, 5ypg, 5yph, 5ypi, 6miu – hSQS-1 ZZ domain
6mj7 – hSQS-1 ZZ domain + Arg
6khz – hSQS-1 ZZ domain + Gly
7r1o – hSQS-1 ZZ domain + drug
2ktr – rSQS PB1 domain – rat - NMR
2kkc – rSQS PB1 domain (mutant) - NMR
4mjs – hSQS-1 PB1 domain + protein kinase C zeta type
3b0f – mSQS UBA domain – mouse
2rru – mSQS UBA domain - NMR
- ↑ Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68. PMID:15340068 doi:10.1128/MCB.24.18.8055-8068.2004
- ↑ Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2012 Jan;96(1):87-95. doi: 10.1016/j.pneurobio.2011.11.005. Epub , 2011 Nov 22. PMID:22138392 doi:https://dx.doi.org/10.1016/j.pneurobio.2011.11.005