Serpin

spinqualitylabelsall models Structure of cleaved human serpin A7. Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry 2xn6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Serpin or serine protease inhibitor (Ser) are protease inhibitors. Ser C1 is Antithrombin. Ser A5 is protein C inhibitor. Ser A6 is Corticosteroid-binding globulin. Ser A8 is angiotensinogen. Ser A7 is a thyroxine-binding globulin. Ser B1 is leukocyte elastase inhibitor. Ser B3 is squamos cell carcinoma antigen 1. Ser B5 is Maspin. Ser crmA is cysteine and serine proteinase inhibitor. Ser I1 is neuroserpin. Ser A10 is protein Z-related protease inhibitor. Ser A1 is Alpha-1-antitrypsin. Ser A3 is α 1-antichymotrypsin. Ser E1 is Plasminogen activator inhibitor. Disease Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency. Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs. Ser A3 promotes growth of endometrial cancer cells . Structural highlights Ser A7 - a thyrosine-binding globulin - binding site contains thyroxin derivative. Water molecules are shown as red spheres. 3D structures of serpin Serpin 3D structures

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Michal Harel, Alexander Berchansky