Serum amyloid P-component

spinqualitylabelsall models Structure of human pentameric SAP (green, grey, pink, yellow, magenta) complex with AMP and Ca+2 ions (green) (PDB code 1lgn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Serum amyloid P-component (SAP) is a plasma protein and is the precursor of amyloid P-component which is constituent of deposits in amyloidosis and Alzheimer disease. SAP binds in a calcium-dependent fashion to a variety of ligands. Relevance Mutations in SAP affect the aggregation of mutated lysozyme which cause amyloidosis. The inhibition of SAP binding to amyloid fibrils is a therapeutic target in some serious human diseases. Small molecule ligands can displace SAP from amyloid fibrils and can provide therapeutic treatment of amyloidosis. Structural highlights The 3D structure of a complex of SAP with the small molecule ligand AMP shows the nucleotide phosphate group bridging two Ca+2 ions and forming hydrogen bonds to Asn, Gln and Try residues of SAP . Ca coordination sites.

3D Structures of serum amyloid P-component

Updated on 22-February-2021

1sac – hSAP – human
2a3w, 2a3x, 2a3y – hSAP + bivalent ligand
1gyk – hSAP + galactose derivative
1lgn – hSAP + AMP derivative
2w08 – hSAP + Thr derivative
4avs, 4avt, 4avv, 4ayu – hSAP + Pro derivative
3kqr – hSAP + ethanolamine derivative
3d5o – hSAP + Igg Fc receptor
1qtj – SAP – Limulus polyphemus

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