Spermidine Synthase

spinqualitylabelsall models Structure of human spermidine synthase complex with spermidine and deoxymethyladenosine (PDB entry 3c6k) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Polyamines are essential in all branches of life. Spermidine synthase (or putrescine aminopropyltransferase, polyamine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine. SPS catalyzes the transfer of aminopropyl group from decarboxylated S-adenosylmethionine (SAM) to the amine acceptor spermidine. N4-Bis(aminopropyl) spermidine synthase or branched-chain polyamine synthase is an aminopropyltransferase essential for synthesis of branched-chain polyamines which enables thermophiles to grow in high temperature environments. Disease SPS deficiency causes the intellectual disability Snyder-Robinson syndrome. Structural highlights SPS active site contains the substrate spermidine. Water molecules are shown as red spheres. 3D structures of spermidine synthase Spermidine synthase 3D structures

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