Sphingomyelinase

spinqualitylabelsall models Sphingomyelinase complex with glycerol and phosphate ion (PDB entry [[21zwx]) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and Ceramide. The SMase is classified into 5 types according to their pH dependence and cation dependence. Acid SMase-like phosphodiesterase is a paralog of acid SMase and thus though related by gene duplication has different functions. Acid SMase-like phosphodiesterase 3A hydrolyzes nucleotides triphosphates and diphosphates. Acid SMase-like phosphodiesterase 3B is a GPI-anchored protein with role in inflammatory processes and kidney disease. Alkaline SMase hydrolyses sphingomyelin in the intestinal tract and bile. See also Lipid signaling. Disease Mutations in acid SMase are found in patients with Niemann-Pick disease.

3D structures of sphingomyelinase

Updated on 14-August-2024

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• SMase
  • Ceramide – hSMase catalytic domain – human
    
  • Lipid signaling, 3rlg – SMase D (mutant) – Loxosceles intermedia
    
  • 1xx1, 2f9r – SMase I – Loxosceles laeta
    
  • 1zwx – SMase C – Listeria ivanovii
    
  • 2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
    
  • 2uyr – BcSMase (mutant)
    
  • 7cne – SMase C – Streptomyces griseocarneus
    
• Acid SMase
  • 5jg8, 5i81, 5i8r – hSMase
    
  • 5i85 – hSMase + phosphocholine
    
  • 5fib – mSMase – mouse
    
  • 5hqn – mSMase catalytic domain
    
  • 5fi9 – mSMase + inhibitor
    
  • 5fic – mSMase + lipid
    
• Acid SMase-like phosphodiesterase
  • 5ebb – hSMase 3A
    
  • 5ebe – hSMase 3A + CMP
    
  • 5fc1, 5fc7, 5fca – mSMase 3A
    
  • 5fcb – mSMase 3A + AMP
    
  • 5fc6 – mSMase 3A + AMPCP
    
  • 5fc5 – mSMase 3A + phosphocholine
    
  • 5kar – mSMase 3B
    
  • 5kas – mSMase 3B + phosphocholine
    
• Alkaline SMase
  • 5udy – hSMase
    
  • 5tcd – hSMase + phosphocholine
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman