Stathmin

spinqualitylabelsall models Rat stathmin SLD domain (magenta) complex with tubulinα chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code 3ryf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Stathmin-4 (STM-4) or stathmin-like protein B3 regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM-4 is an oncoprotein. STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer. Disease Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease. 3D Structures of stathmin-4 Stathmin-4 3D structures

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