Strictosidine Synthase

spinqualitylabelsall models Strictosidine synthase dimer complex with tryptamine (PDB entry 2fpb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The enzyme strictosidine synthase (STR1) (EC 4.3.3.2) from an Indian medicinal plant Rauvolfia serpentina is of primary importance for the biosynthetic pathway of the indole alkaloid ajmaline. STR1 initiates all biosynthetic pathways leading to the entire monoterpenoid indole alkaloid family representing an enormous structural variety of ~2000 compounds in higher plants. The enzyme is involved in the biosynthesis of all these alkaloids by catalyzing the condensation of the two initial building blocks, tryptamine and the monoterpenoid secologanin, leading to the glucoalkaloid strictosidine. The reaction type catalyzed by STR1 is so far an exceptional example in the biosynthesis of natural products. It was hitherto known only from synthetic chemistry (Pictet-Spengler–type reaction), where it is applied in alkaloid synthesis, especially of tetrahydroisoquinolines by condensation of an amine and an aldehyde under acidic conditions. The overall structure of the enzyme contains a six-bladed four-stranded ß-propeller fold. All six blades are radially arranged around a pseudo six-fold symmetry axis. Each blade contains a twisted four-stranded antiparallel ß-sheet. Structural highlights The substrate binding pocket of STR1 is located near the pseudo six-fold symmetry axis. Alpha Helices,  Beta Strands ,  Loops , Turns. Active site. Water molecule are shown as red sphere.

3D structures of strictosidine synthase

Updated on 06-December-2023

2fp8 – sSTR1 – serpentwood
3v1s – dSTR - devilpepper
2fp9 – sSTR1 + tartaric acid

2fpb – sSTR1 (mutant) + tryptamine

2fpc – sSTR1 + secologanin

2v91 – sSTR1 residues 32-333 + strictosidine

2vaq – sSTR1 + inhibitor
6n5v, 7t5i, 7t5j – sSTR + indole derivative
4imb, 4iyg – dSTR + indole derivative
6s5q, 6s5u, 6s5j, 6s5m – STR + carboline derivative – Ophiorrhiza pumila
6zea – STR + carboline derivative – periwinkle

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