Sulfotransferase

spinqualitylabelsall models Human estrogen sulfotransferase dimer complex with cofactor PAP, 1hy3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sulfotransferase (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system. The various human STs are named SULT1, SULT2, SULT4 and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP). Estrogen sulfotransferase sulfates estrogen to inactivate it. Involved in sulfation of thyroid hormones. Heparan sulphate sulfotransferase sulfates iduronic acid and glucosamine. Tyrosylprotein sulfotransferase performs a post translational protein modification by catalysing the transfer of sulphate to Tyr residues. Sulfotransferase 1A1, 1A2 are human enzymes which sulfate small planar phenols like neurotransmitters and steroid hormones, . Sulfotransferase 1A3 is a human enzyme which sulfates dopamine. Sulfotransferase 1C3 is a human enzyme expressed in intestines. Sulfotransferase 1E1 is a human enzyme which sulphates ethinyl estradiol. Sulfotransferase 2A1 is a human enzyme which sulphates 25-hydroxyvitamin D3. Sulfotransferase 2B1, 2B2 are human enzymes which sulphate steroids. Sulfotransferase 4A1 is a human enzyme expressed in the brain. Sulfotransferase 2A8 is a mouse enzyme which sulphates 7α-hydroxyl bile acid. Sulfotransferase STF0 is a microbial enzyme which sulphates trehalose. Relevance Reduced level of ST expression and activity is observed in liver diseases. Structural highlights ST catalytic residues His and Lys interact with the sulfate donor molecule PAP. Whole active site. Water molecules are shown as red spheres. 3D structures of sulfotransferase Sulfotransferase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman