Survivin

spinqualitylabelsall models Structure of human survivin dimer (magenta and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code 3uig). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Survivin or apoptosis inhibitor 4 or baculoviral IAP repeat-containing protein 5 (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation. Survivin is part of the chromosomal passanger complex (CPC) which includes also Borealin and INCENP . Disease IAP4 is found in human cancer cells. and can serve as a cancer marker and as a target for chemotherapy. Human survivin interactions with histone H3 peptide (PDB code 3uig). Zn coordination site in the human survivin (PDB code 3uig).

3D structures of survivin

Updated on 14-April-2022

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• Survivin
  • Borealin, INCENP – hIAP4 – human
    
  • 3uig, 3uig, 3ueh, 3uei – hIAP4 (mutant)
    
  • 1xox – hIAP4 – NMR
    
  • 1m4m – IAP4 – mouse
    
• Survivin complexes
  • 2raw, 2rax – hIAP4 + Borealin N-terminal
    
  • 2qfa, 6yie – hIAP4 + Borealin N-terminal + inner centromere protein
    
  • 6yif, 6yih – hIAP4 + Borealin N-terminal + inner centromere protein + histone H3 peptide
    
  • 4a0i – hIAP4 + shugoshin peptide
    
  • 4a0j, 4a0n, 3uig, 3uii, 3ued, 7lbk, 7lbo, 7lbp, 7lbq – hIAP4 + histone H3 peptide
    
  • 3uik, 3uec, 3uee, 3uef – hIAP4 (mutant) + histone H3 peptide
    
  • 3uih – hIAP4 + diablo peptide
    
  • 3uij – hIAP4 (mutant) + diablo peptide
    

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Michal Harel, Alexander Berchansky