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Function
Syntaxin-binding proteins (STXBP) are involved in the regulation of synaptic vesicle docking and fusion. STXBP1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding Syntaxin-1 and as a fusion protein that binds SNARE complexes in a Syntaxin-1 N-peptide-dependent manner[1]. STXBP2 binds SNARE proteins.
Structural highlights
Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1 which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions[1].
- ↑ 1.0 1.1 Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A. 2010 Dec 30. PMID:21193638 doi:10.1073/pnas.0914906108
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3D structures of syntaxin-binding protein
Updated on 11-December-2023
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- Syntaxin-binding protein 1 or Munc18-1
- Syntaxin – rSTXBP1 (mutant) – rat
- Syntaxin, 4jeu, 3c98 – rSTXBP1 + STX-1a
- 7udb, 7udc – rSTXBP1 + synaptobrevin-2 + STX-1a – Cryo EM
- 3puj – rSTXBP1 + syntaxin 4 peptide
- 7xsj – rSTXBP1 + Syntaxin 1a N-terminal+SNARE motif + amyloid-beta A4
- Syntaxin-binding protein 2 or Munc18-2
- Syntaxin-binding protein 3 or Munc18-3
- 3puk – rSTXBP3 + syntaxin 4 peptide
- Syntaxin-binding protein 4
- 1wi4 – mSTXBP4 PDZ domain – mouse - NMR
- 2ysg – mSTXBP4 WW domain - NMR
References
