Syntenin

spinqualitylabelsall models Human syntenin PDZ1+PDZ2 domains (deep sky blue and green) complex with syndecan-4 peptide (pink and yellow) (PDB id 1ybo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Syntenin (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes Relevance Exosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases. SYNT is over-expressed in breast and gastric cancer Structural highlights The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains. The peptide forms a β strand which runs antiparallel to the PDZ β strand. Syntenin/Syndecan peptide inreactions. Water molecules are shown as red spheres. Syntenin 3D structures 3D structures of syntenin

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Michal Harel, Alexander Berchansky